The cells. This topic is relevant to the course

The
heart is the first organ to function in a human embryo, and plays a huge role
in supplying both oxygen and nutrients to the rest of the tissues throughout
the development process, and throughout the lifetime of a human. Therefore,
understanding how heart development is regulated is extremely important in
better understanding congenital heart disease and for developing new
therapeutic targets. A limitation to heart development research, according to
Liu et al. (2017), is that there are differences in the development between
mice and humans, even though many of the transcription factors that play a role
in heart development in mice are conserved in humans. This draws the conclusion
that there may be species-specific regulators that play a role in heart
development. Liu et al. (2017) have discovered a non-coding region of the
genome in humans, not highly conserved, that acts in a complex to control
cardiomyocyte differentiation from human pluripotent stem cells.

 

  This topic is relevant to the course as by
understanding how the differentiation from pluripotent stem cells to
cardiomyocyte occurs, we can develop a further understanding of cardiac muscle
formation. Cardiac muscle, itself, plays a very
important role as it allows for the chambers to contract and permits effective
blood flow throughout the body, and injury to cardiac muscle may lead to heart
failure. Therefore, understanding how cardiomyocyte differentiation is
regulated may open doors to new targets for treatment options. Even further, this
may increase the understanding of other developmental processes by opening the
door to look at other non-coding regions to see if they are involved with not
just heart development, but also, the development of other organs. 

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